A lower starting dosage and slower titration may be considered for some patients as clinically indicated
When converting to TRILEPTAL monotherapy, concomitant antiepileptic drugs should be completely withdrawn over 3 to 6 weeks, while the maximum dosage of TRILEPTAL should be reached in about 2 to 4 weeks
*
In patients with renal impairment (creatinine clearance <30 mL/min), TRILEPTAL should be initiated at one half the usual dosage and increased slowly.
†
When TRILEPTAL is used as add-on therapy at dosages >1200 mg/day, a decrease in the dose of phenytoin may be required.